http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108066287-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_be8860f214c3ff1219f004387b93f36a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-662 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-662 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 |
| filingDate | 2016-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108066287-A |
| titleOfInvention | Application in the preparation method and its protection mitochondria of the MitoPBN liposomes of efficient targetted mitochondria and anti anoxia damage |
| abstract | Denomination of invention：Application in the preparation method and its protection mitochondria of the MitoPBN liposomes of efficient targetted mitochondria and anti anoxia damage.The preparation method of liposome is existing mainly membrane-sonic method, reverse evaporation, injection method etc..The present invention lecithin, cholesterol are mixed with MitoPBN powder according to the proportioning of optimization after with chloroform dissolve rotary evaporation, physiological saline quickly revolving two hours, the nano particle of last ice-water bath ultrasound to 100nm or so are added in after continuing the ventilation regular hour after nitrogen is passed through to the pungent smell of no chloroform.It is suitable that MitoPBN liposomal particle size sizes are made in this approach, and stability height, envelop rate is high, and the time used is short.MitoPBN liposomes carrying drug ratio of the invention is high after testing, strong into cell ability, and targeting in vivo is enriched in the mitochondria position of internal organs.This MitoPBN liposomes can be used for the drug for preparing prevention anoxia-induced apoptosis, protects mitochondria, can also have broad application prospects in the clinical practice of the relevant disease of other mitochondrial damages. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107510848-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110151700-A |
| priorityDate | 2016-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.