http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108066283-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-138 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-138 |
| filingDate | 2017-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108066283-B |
| titleOfInvention | Preparation method of levobetaxolol hydrochloride eye drops |
| abstract | The invention discloses a preparation method of levobetaxolol hydrochloride eye drops, which comprises the following steps: adding 0.5 percent of polystyrene sulfonic acid into 5 to 15 percent of water for injection, crushing and stirring to prepare suspension; adding 0.2-0.6% of carbomer into 15-20% of water for injection, stirring uniformly, and swelling; adding 0.5% of levobetaxolol hydrochloride and 2% -6% of mannitol into 40% of water for injection, heating, stirring for dissolving, and filtering to obtain a mixed solution A; adding the suspension into the mixed solution A, and stirring and mixing to obtain a mixed solution B; adding the swelled carbomer solution into the mixed solution B, and stirring and mixing to obtain a mixed solution C; adding boric acid, edetate disodium, benzalkonium chloride and sodium lauroyl sarcosine into 15% of water for injection, stirring for dissolving, filtering, adding the filtered liquid into the mixed liquid C, and stirring and mixing to obtain a mixed liquid D; and (3) regulating the pH of the mixed solution D to 6.5-7.5 by using 0.03-0.09% of pH regulator, adding water for injection to constant volume, stirring, heating, sterilizing and cooling to obtain the product, wherein the product is simple in preparation process and good in stability. |
| priorityDate | 2017-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.