http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108059667-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-655 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-14 |
| filingDate | 2018-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108059667-B |
| titleOfInvention | A kind of solid phase synthesis process of Lanreotide |
| abstract | It the present invention relates to a kind of solid phase synthesis process of Lanreotide, solves that prior art liquid-phase synthesis process reaction step is cumbersome, the reaction time is long, solvent dosage is big, isolates and purifies difficult technical problem.The present invention provides a kind of solid phase synthesis process of Lanreotide; using Fmoc- amino resins as the carrier of synthesis in solid state; it is condensed 8 protected amino acids successively; the linear peptide resin of precursor of Lanreotide is obtained, disulfide bond cyclization is then carried out, obtains Lanreotide peptide resin; carry out being formed the cyclization of disulfide bond by the way of phase oxidative; finally peptide resin is cracked, sloughs Side chain protective group, Lanreotide crude product is obtained, purifies to obtain Lanreotide sterling.The present invention is widely used in polypeptide drugs preparing technical field. |
| priorityDate | 2018-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 239.