http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108059666-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-605 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-36 |
| filingDate | 2018-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108059666-B |
| titleOfInvention | A kind of method that solid-liquid combination prepares Suo Malu peptides |
| abstract | The present invention relates to a kind of method that solid-liquid combination prepares Suo Malu peptides, solves the prior art and synthesize the technical issues of synthesis cycle is long, purifying difficulty is big, low yield during long sequences polypeptide.The present invention provides a kind of method that solid-liquid combination prepares Suo Malu peptides, uses solid phase synthesis process by Lys in the form of Alloc Lys (Fmoc) OH and resin condensation first, removing side chain ε NH 2 On Fmoc protecting groups, be attached side chain; Alloc Lys (PEG PEG γ Glu (OtBu) Monobutyl octadecanate) OH is obtained through cracking, while using simultaneously synthesizing 10 dipeptides of liquid-phase synthesis process or tripeptides or four peptide fragments；The condensation reaction of synthesized peptide fragment and single amino acids is carried out using resin as carrier again, this process reduces 15 step solid phase condensation reactions, reduce the generation of disappearance peptide impurity, improve product purity and yield；The generation for effectively avoiding impurity [+Gly] Suo Malu peptides and [+Ala] Suo Malu peptides simultaneously, greatly reduces purifying difficulty.The present invention is widely used in polypeptide drugs preparing technical field. |
| priorityDate | 2018-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 179.