http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108048564-B
Outgoing Links
Predicate | Object |
---|---|
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-136 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6883 |
filingDate | 2018-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2021-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2021-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-108048564-B |
titleOfInvention | New application of human GLT8D1 gene |
abstract | The invention discloses a new application of human GLT8D1 gene, namely applying a human GLT8D1 gene expression level detection reagent in preparing a clinical diagnostic reagent for schizophrenia; and the low expression of the human GLT8D1 gene is applied to screening drugs for treating schizophrenia, and the experimental result shows that: GLT8D1 has a regulating effect on the proliferation, self-renewal and differentiation of neural stem cells in vitro; after the GLT8D1 gene is knocked down, the length, the number and the bifurcation number of the neurites of the neurons are obviously reduced compared with those of a control group; the knock-down of the GLT8D1 gene in neurons significantly altered the frequency of the mini excitatory postsynaptic current and the amplitude of the mini inhibitory postsynaptic current; this provides evidence that GLT8D1 is a risk gene for schizophrenia; the invention discloses that the GLT8D1 gene is a potential risk gene of schizophrenia for the first time, and provides a new biomarker for clinical diagnosis of schizophrenia. |
priorityDate | 2018-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 214.