http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108048402-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0331 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0694 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5044 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate | 2018-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108048402-B |
| titleOfInvention | A kind of people's Pancytopenia glucocorticoid drug-resistant cell strain and its construction method and application |
| abstract | The present invention provides a kind of people's Pancytopenia glucocorticoid drug-resistant cell strain CEM-C7/HDR and its construction method and application, its deposit number is CCTCC NO:C2017233, the cell strain is induction object with Pancytopenia glucocorticoid sensitive cells strain CEM-C7-14, simulate Pancytopenia cell living environment in marrow, it obtains stablizing glucocorticoid drug resistant cell strain CEM-C7/HDR using 0.25 μM of dexamethasone, 1 Fiber differentiation, it is to 1500 times or more that the half-inhibitory concentration of dexamethasone is parental cell.The present invention provides new cell model for the research and biological medicine research and development for recurring refractory people's acute lymphoblastic leukemia, has biggish practical value in the application for exploring the drug resistant pathogenesis of people's Pancytopenia glucocorticoid, the refractory mechanism of recurrence and reversing drug resistance medicament research and development. |
| priorityDate | 2018-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.