http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108048394-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_217f2be73fd6be0be36dd55803d3bec5 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-137 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2533-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2513-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-2301 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-32 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0655 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-077 |
| filingDate | 2017-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c33778b9985f5fabbe97c88f05baecc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_526845287ee440b67cf71bcb3ba37213 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90a96f3c36fdddc1677c40b6209d88a2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96da3afbf3512baf7e634d0cced6a384 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db1d9a6300b1c1e2b77d0a10e61484b5 |
| publicationDate | 2018-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108048394-A |
| titleOfInvention | A kind of method that two-step method establishes osteoarthritis like cell model after mescenchymal stem cell cartilage differentiation |
| abstract | The invention discloses a kind of methods that two-step method establishes osteoarthritic cells model after mescenchymal stem cell cartilage directed differentiation.This method inducing mesenchymal stem cell directed differentiation first is articular chondrocytes, then establishes osteoarthritis using the external evoked gained cartilage cells of 1 β of IL.The present invention establishes osteoarthritis after cartilage directed differentiation using two-step method for the first time, is changed by investigating cartilage cell's morphology and phenotype genes aggrecan, Col2 α 1 expression, it is determined that the optimal use concentration of solution and cell induction time.This method operation easily, cost it is relatively low, available for correlative studys such as cell quality assessment, the susceptible early warning of adult osteoarthritis, the verification of osteoarthritis drugs action target and the screenings of drug toxicity/drug effect after mescenchymal stem cell cartilage directed differentiation. |
| priorityDate | 2017-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 137.