http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108046276-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C01P2006-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C01P2004-04 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y40-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C01B33-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y40-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C01B33-18 |
| filingDate | 2017-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108046276-B |
| titleOfInvention | A kind of polyethyleneglycol modified preparation of mesoporous silica nano-particle of carboxy blocking and application thereof |
| abstract | The present invention provides a kind of preparation method of the polyethyleneglycol modified mesoporous silica nano-particle of carboxy blocking, the polyethylene glycol (HOOC-PEG-COOH) of both-end carboxy blocking is soluble in water, 1- ethyl-(3- dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) is added, n-hydroxysuccinimide (NHS) is added after stirring 10-15min, after reaction activation 0.5-1h, then it is slowly added to amido modified mesoporous silicon dioxide nano particle (CMS-NH dropwise 2 ), 4-12h is reacted at room temperature, centrifugation is washed with distilled water 3-5 times, is dispersed in water preservation, obtains the polyethyleneglycol modified mesoporous silica nano-particle CMS-PEG-COOH of carboxy blocking.The present invention will be polyethyleneglycol modified to mesoporous silicon dioxide nano particle sublist face with both-end carboxy blocking by amido bond, improves the colloidal stability of nanoparticle.After the material modifies nanoparticle, carboxyl functional group is contained in end can realize that the targeting of drug conveys in conjunction with many targeted moleculars. |
| priorityDate | 2017-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 82.