http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108033902-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-09 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-44 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-40 |
| filingDate | 2017-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108033902-B |
| titleOfInvention | Preparation method of high-purity cis-isomer of belinostat |
| abstract | The invention provides a preparation method of cis-isomer of belinostat, which takes 3-phenyl amino sulfonyl benzaldehyde as an initial raw material, after Wittig condensation reaction and hydrolysis, the hydrolysis intermediate product is split, separated and purified to obtain cis-hydrolysis intermediate, chlorination and hydroxylamine condensation reaction are carried out to obtain a crude product of a compound II, and the crude product of the belinostat with the purity of more than 98 percent can be obtained after solvent pulping and purification. The method is simple and convenient to operate, the yield is high, the preparation of liquid phase separation and purification are not needed, and the obtained cis-isomer of the belinostat can be used as an impurity reference substance for checking related substances of the belinostat. |
| priorityDate | 2017-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 77.