http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108017657-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-12 |
| filingDate | 2017-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108017657-B |
| titleOfInvention | Refining method of cefprozil |
| abstract | The invention relates to a cefprozil refining method, which comprises the synthesis of a cefprozil crude product and the refining of cefprozil, wherein the refining comprises the following steps: 1) adding the cefprozil crude product into ethanol, stirring, adjusting the pH to 2.0-2.2 by using a dilute hydrochloric acid aqueous solution, stirring, dissolving the crude product, and filtering to obtain a cefprozil salt crude product solution; 2) dropwise adding a 4% sodium bicarbonate solution into the solution, adjusting the pH to 4.6-5.0, cooling, keeping the temperature, stirring, performing suction filtration, washing, and draining to obtain a solid; 3) dissolving the solid obtained in the step 2) in water, adding activated carbon, heating to 30-35 ℃, fully stirring, filtering to obtain a filtrate, cooling the filtrate to 0-5 ℃, adding the filtrate into the mixed solvent, crystallizing, controlling the temperature and the stirring speed to grow crystals for 1.5h, filtering, washing, draining, and drying in vacuum to obtain a pure cefprozil product. The refining method provided by the invention has the advantages of simple conditions, high cis-isomer content and the like. |
| priorityDate | 2017-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 77.