http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108017639-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 |
| filingDate | 2016-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108017639-B |
| titleOfInvention | IDO inhibitor and preparation method and application thereof |
| abstract | The invention provides pharmaceutically acceptable salts, isomers, racemates, non-corresponding isomers and pharmaceutical compositions of formula I, formula II, formula III or formula IV, and application thereof in treating diseases related to indoleamine 2,3-dioxygenase (IDO), in particular application thereof in treating various major diseases such as tumors, Alzheimer's disease, depression, cataract and the like; r, R therein 2 The definitions of the groups such as W and the like are shown in the specification. The results of preliminary drug activity studies show that the compound has significant IDO inhibitory activity. Simultaneously, SD rats are taken as tested animals, and LC/MS is appliedThe method determines the drug concentration in the blood plasma of a rat at different times after the rat is administrated with the compound by gavage, and researches the pharmacokinetic behavior of the compound in the rat body, and the result shows that the compound has obvious drug absorption effect and better clinical application prospect. |
| priorityDate | 2016-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 254.