http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108003141-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4370fae00bcd148352b93eaaf19c9c04 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-48 |
| filingDate | 2017-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0bd7045d522c1374cb45c603b4a6b8d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a6596c2cea091a09df4b53ac51ebc71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7941a94dbe8ecaf3c415e45ea6b16183 |
| publicationDate | 2018-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108003141-A |
| titleOfInvention | A kind of modified technique for preparing quinazoline ditosylate salt medicine |
| abstract | The present invention relates to a kind of modified technique for preparing quinazoline ditosylate salt medicine, there is provided and it is a kind of with the synthetic route that 2 chlorine, 4 amino, 6,7 dimethoxyquinazoline is intermediate, specifically comprise the steps of：Acrylonitrile occurs aminating reaction with methylamine alcohol solution and obtains intermediate (I)；Under conditions of triethylamine does acid binding agent protection group generation intermediate (II) is done with benzyl chloride；Hydride reduction generation intermediate (III) is answered using metal；Acylation reaction occurs with tetrahydrofuran formyl chloride and obtains intermediate (IV)；Under palladium carbon catalysis with ammonium formate hydrogenolysis occurs for intermediate (IV) up to intermediate (V)；Condensation reaction finally occurs with 2 chlorine, 4 amino, 6,7 dimethoxyquinazoline, up to quinazoline ditosylate salt medicine alfuzosin (VI).Compared to other production technologies, present invention offer is a kind of easy to operate, and safety, reaction condition is easily controllable, and energy consumption is low, the production technology of stable yield, and has good industrial applications prospect. |
| priorityDate | 2017-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 91.