http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107987168-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-31 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0058 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2863 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-16 |
| filingDate | 2017-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107987168-B |
| titleOfInvention | Single-chain double-specific antibody for resisting VEGF and EGFR and application thereof |
| abstract | The invention discloses a single-chain bispecific antibody for resisting VEGF and EGFR, which is formed by fusing an anti-VEGF antibody light chain and an anti-EGFR antibody heavy chain through connecting peptides, has two groups of unique CDR (complementary deoxyribonucleic acid) region sequences capable of respectively identifying VEGF and EGFR, has high specific identification capacity for VEGF and EGFR, has excellent tumor binding effect, and has specific binding for different types of tumor cell lines. The invention also discloses the application of the antibody coupled with the indicator in preparing in-vitro tumor diagnosis reagent and in-vivo biological imaging agent. When the imaging agent is applied to a tumor animal model, the single-chain antibody marked with the near-infrared fluorescence and nuclear magnetic imaging agent can clearly show the size and the position of a mouse tumor, and has extremely high in-vivo imaging capability. |
| priorityDate | 2017-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 230.