http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107987021-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9add8f0d3e428b7654b0541d170c3e08 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-14 |
| filingDate | 2017-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad272851ab4771d2caa24dcf8a26192d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7cc74fe0d617cebd6f167f836a7d4940 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16ebbdc18c2c9f8519042a904bfd3784 |
| publicationDate | 2018-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107987021-A |
| titleOfInvention | A kind of preparation method of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid |
| abstract | The invention provides a preparation method of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid, 1,1,1-trichloro-3-(substituted aminomethylene)-5 , 5-difluoro-2,4-pentanedione reacts with n-alcohol to generate 2-(substituted aminomethylene)-4,4-difluoro-3-oxo-butyrate under the action of a base, and then React with methylhydrazine aqueous solution to generate 3-difluoromethyl-1-methyl-1H-pyrazolyl-4-formate, and finally hydrolyze under alkaline conditions to obtain 3-difluoromethyl-1-methyl -1H-pyrazole-4-carboxylic acid. The present invention provides a kind of new economical method, first obtains 2-(substituted aminomethylene)-4,4-difluoro-3-oxo-butyrate with high yield and high purity, and then with high selectivity Conversion to the desired product 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021022761-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11472775-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110577477-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113912541-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110577503-A |
| priorityDate | 2017-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.