| abstract |
The present disclosure relates to an isolated compound comprising a phosphorothioated oligodeoxynucleotide (ODN) sequence conjugated to a short activating RNA (saRNA) or antisense oligonucleotide sequence (ASO), and compositions of such compounds , and methods of treating cancer and autoimmune diseases (with or without stimulation of an immune response), methods of immunostimulation, methods of activating CEBPA, and activating STAT transcription factors achieved by a disclosed compound or composition lowering method. |