| abstract |
The invention discloses a 2-[(3,3,3-trifluoropropyl)thio]-6-amino-9H-purine and a preparation method thereof. The 2-[(3,3,3-trifluoropropyl) Fluoropropyl)thio]-6-amino-9H-purine, which can be used to prepare 6-N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl) Thio]adenosine. The invention has the advantages of simple and convenient operation, mild reaction conditions, easy purification of intermediates, high reaction yield in each step, and avoids the reported key intermediate of cangrelor 6-N-[2-(methylthio)ethyl]-2- [(3,3,3-trifluoropropyl)thio]adenosine has defects and deficiencies in the preparation method, and is suitable for industrial production. The structural formula of 2-[(3,3,3-trifluoropropyl)thio]-6-amino-9H-purine is as follows: |