http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107973779-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 |
| filingDate | 2018-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107973779-B |
| titleOfInvention | Preparation method of N- (2-pyridine/pyrimidine-based) indole derivative |
| abstract | The invention discloses a preparation method of an N- (2-pyridine/pyrimidine-based) indole derivative, which comprises the following steps: uniformly mixing a 2-substituted phenyl aminopyridine/pyrimidine derivative, an alkenyl azide compound, a catalyst, an oxidant, an alkali and an organic solvent, heating to 60-80 ℃ under nitrogen or air, carrying out cyclization reaction for 18-24 h, cooling to room temperature after the reaction is finished, and carrying out concentration and column chromatography purification to obtain the N- (2-pyridine/pyrimidine) indole derivative. The invention can synthesize N- (2-pyridine/pyrimidyl) indole derivatives with various substituents which can not be synthesized by other methods, and has the advantages of easily obtained raw materials, high yield, mild reaction conditions, short reaction time, wide substrate range, strong reaction specificity, simple and green post-treatment. |
| priorityDate | 2018-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 87.