| abstract |
The invention provides a m-disubstituted phenol compound with a general formula (I), a preparation method and application thereof. The m-disubstituted phenol compound has a new parent nucleus structure of an anti-tubercle bacillus drug and excellent anti-tubercle bacillus activity, and particularly has strong inhibitory activity on drug-resistant variant tubercle bacillus strains. The invention also provides a preparation method of the m-disubstituted phenol compound, the raw materials of the preparation method are cheap and easy to obtain, high-toxicity and high-pollution reagents are not needed, the reaction steps are simple, and the industrial production can be realized; has good medicinal prospect. |