http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107964558-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P35-00 |
| filingDate | 2017-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107964558-B |
| titleOfInvention | Preparation method of cefotiam hydrochloride impurity destetrazolium cefotiam |
| abstract | The inventionDiscloses a preparation method of cefotiam hydrochloride impurity 3-methyl cefotiam hydrochloride, which adds POCl into an organic solvent 3 And DMF, adding aminothiazole acetate for reaction, adding a mixed solvent for crystallization after 12-24 hours, growing crystals, filtering and washing; adding 7-ADCA into the mixed solution, adding organic base to adjust the pH value, adding aminothiazole acetyl chloride when 7-DACA is dissolved, adding an organic solvent when the residue is less than 1.0%, standing for phase separation, collecting a water phase, adding acetone and concentrated hydrochloric acid, growing crystals, filtering, washing and drying to obtain the 3-methyl cefotiam hydrochloride. The method solves the bottleneck problem in the research and development process of cefotiam hydrochloride, changes the product form of impurities, improves the product stability, obtains the impurity reference substance with high purity and stable property, fills the blank of the preparation process of the impurity reference substance, effectively shortens the synthesis steps, achieves the yield of 115 percent, reduces the cost to about 600 yuan/KG, and reduces the synthesis cost of the impurities. |
| priorityDate | 2017-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.