http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107963987-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-401 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06165 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-401 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-078 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 |
| filingDate | 2016-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107963987-B |
| titleOfInvention | A stachydrine derivative, its preparation method and application in preparing medicine for treating cardiovascular disease and cerebrovascular disease |
| abstract | The invention provides a stachydrine derivative, a preparation method thereof and application thereof in preparing medicaments for treating cardiovascular and cerebrovascular diseases, wherein the stachydrine derivative has a structure shown in a general formula (I), and the synthesis method comprises the following steps: L -proline a and formaldehyde are subjected to hydrogenation reaction under the catalytic action of a catalyst to prepare the compound N -methyl- L -proline b; N -methyl- L Proline b with anthranilic acid, γ Condensation reaction of aminobutanamide, glutamine and glycine under the action of Dicyclohexylcarbodiimide (DCC) to obtain stachydrine derivatives B-1, B-2, B-3 and B-4. Pharmacological experiments prove that the stachydrine derivative provided by the invention has the effect of protecting nerves and treating cardiovascular and cerebrovascular diseases, and the invention also provides application of the stachydrine derivative in preparing a medicament for treating the cardiovascular and cerebrovascular diseases. |
| priorityDate | 2016-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 196.