| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-542
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-543
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55544
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-16134
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-16122
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-18534
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-18522 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-145
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-39
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-155 |
| filingDate |
2017-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2020-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2020-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-107961371-B |
| titleOfInvention |
Seasonal influenza-RSV combined vaccine and preparation method and application thereof |
| abstract |
The invention discloses a seasonal influenza-RSV combined vaccine, a preparation method and an application thereof, comprising the following steps: a fusion protein of seasonal influenza virus protein and Respiratory Syncytial Virus (RSV) and an immunologic adjuvant. The fusion protein is selected from highly conserved protein sequences of seasonal influenza viruses and respiratory syncytial viruses, and the constructed fusion protein and an immune adjuvant are (0.5-2): 1 to obtain the seasonal influenza-RSV combination vaccine. The recombinant fusion protein adopted by the invention is used as a novel antigen, and the IgG in serum and the IgA antibody titer of a mucous membrane system are increased when the recombinant fusion protein is administrated through mouth and nose. The invention has the advantages that the common immune response aiming at seasonal influenza and RSV is caused, and the mucosal adjuvant is matched to cause mucosal immunity, thereby enhancing the immune effect. |
| priorityDate |
2017-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |