abstract |
The present invention provides a human ECM-pneumococcal combined vaccine based on recombinant ΔfHbp-NadA fusion protein carrier and a preparation method thereof. Through the design of soft linking peptide chains, the two active proteins are fused and expressed, and then the two become a single protein while maintaining their respective activities. Therefore, it is more controllable in industrial production and immunization, and the risk is greatly reduced. Provide more polysaccharide-protein binding sites to achieve the effect of multiple immunizations with one administration. |