| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_caacf483b6be9ae2d2677103a70559db |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1007 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0057
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-14 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-14 |
| filingDate |
2017-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7275795959dfc8c37a2a31827dee5dae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_789f0fc3300ab4b302c2c73a60c08ec4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16614330c737ae4f570e917ad1449974 |
| publicationDate |
2018-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-107954994-A |
| titleOfInvention |
Long-lived fluorescein derivatives with hypoxia targeting, their synthesis and biological applications |
| abstract |
The invention discloses a class of long-lived fluorescein derivatives with hypoxia targeting, their synthesis method and biological application, wherein L is ‑CH 2 ‑O‑CH 2 ‑, CO‑O‑CO‑ or ‑COO‑CH 2 ‑; R is a symmetrical structure of C 10 H 8 N 2 O, C 8 H 8 O and C 6 H 6 OS. The long-lived fluorescein derivative I of the present invention can be used for the detection of nitroreductase (NTR) in hypoxic tumor tissue, and at the same time, because the derivative I has a longer triplet excited state lifetime, it can generate a singlet state Photodynamic therapy for hypoxic tumors. This traditional dye-based fluorescein derivative has a therapeutic-integrated effect and has the potential to play a role in biological applications. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108853495-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111718320-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110016238-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109988141-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109988141-A |
| priorityDate |
2017-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |