| abstract |
The invention discloses a class of 2-azabicyclo[4.2.0]octane compounds, as shown in formula III or formula IV, and discloses its preparation method, formula III can also be synthesized as shown in formula V, VI, VII compound. The compounds represented by the formulas III, IV, V, VI and VII have antitumor activity and can be used to prepare antitumor drugs. The method of the present invention provides a kind of effective by common photosensitizer catalyst, visible light is used as light source, by 1,4-dihydropyridine and alkene that are cheap and easy to obtain as substrate high-efficiency high regio, stereoselective synthetic 2-aza A method for bicyclo[4.2.0]octanes. This method uses visible light to promote the [2+2] cycloaddition reaction between different molecules to construct multi-substituted 2-azabicyclo[4.2.0]octane compounds; the substrate range is wide, including a variety of different types of alkenes And various 1,4-dihydropyridines, the reaction conditions are mild, the operation is simple, and the atom economy is high; the yield of the reaction is also good, generally 56% to 99%, and the stereoselectivity is good. |