http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107954888-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-10 |
| filingDate | 2017-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107954888-B |
| titleOfInvention | Synthetic method of cooling agent N,2, 3-trimethyl-2-isopropyl butanamide |
| abstract | The invention discloses a method for synthesizing cooling agent N,2, 3-trimethyl-2-isopropyl butanamide, which comprises the following steps: (1) reacting methyl acetoacetate with 2-bromopropane under the strong alkali condition to obtain 3, 3-diisopropyl methyl acetoacetate; (2) reacting the obtained 3, 3-diisopropyl methyl acetoacetate with ethylene glycol to protect ketone carbonyl, hydrolyzing ester into hydroxyl under the action of a reducing agent, reacting with p-methylbenzenesulfonyl chloride, and removing p-toluenesulfonate to obtain 3-isopropyl-4-methyl-2-pentanone; (3) reacting 3-isopropyl-4-methyl-2-pentanone with hydroxylamine hydrochloride, and performing Beckmann rearrangement under an acid condition to obtain N,2, 3-trimethyl-2-isopropyl butyramide. The method successfully obtains the N,2, 3-trimethyl-2-isopropyl butyramide through ester methylation and Beckmann rearrangement, provides a new synthesis method for synthesizing WS-3, has higher yield, and is suitable for large-scale production. |
| priorityDate | 2017-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.