http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107936059-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c6ed83b9d5c28c6c356d1d08d58501e7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65616 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6561 |
| filingDate | 2017-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df7e192770897c5ba843b2d6db569f9f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de5331217318ff6be5d61aa281b43611 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25aadd7edfcee7929f082cbf3f2982dc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8e6da0eabcf0a778f024183ca023b8a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ee60bc166359e7c357c5537d623d0bb |
| publicationDate | 2018-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107936059-A |
| titleOfInvention | A kind of improved method of synthesis process of n-hexadecyloxypropyl tenofovir disoproxil |
| abstract | The invention discloses an improved method for the synthesis process of n-hexadecyloxypropyl tenofovir disoproxil, belonging to the technical field of organic synthesis. The present invention adopts following technical scheme, comprises the following steps: 1. n-hexadecyl bromide (2) and 1,3 propanediol (3) react to obtain 3-hexadecyloxy propanol (4); 2. PMPA (5) Acid chloride intermediate (6) is obtained through chlorination; ③ acid chloride intermediate (6) and 3-n-hexadecyloxypropanol (4) are esterified to obtain intermediate (7); ④ intermediate (7) is hydrolyzed, Recrystallized to obtain n-hexadecyloxypropyl tenofovir disoproxil (1), the total yield is about 62%, and the purity is greater than 99%. Its main advantages are that the materials are easy to obtain, the operation is simple, the cost is low, and it is beneficial to industrial production. |
| priorityDate | 2017-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 19.