http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107929812-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-446 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-46 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-46 |
| filingDate | 2017-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107929812-B |
| titleOfInvention | Preparation method of biomimetic mineralized collagen scaffold |
| abstract | The invention provides a preparation method of a biomimetic mineralized collagen scaffold, which comprises the following steps of 1) preparation of biomimetic mineralized liquid: adjusting the pH of the carboxymethyl chitosan-amorphous calcium phosphate (or amorphous strontium phosphate or amorphous strontium carbonate) nanocomposite solution to be lower than the isoelectric point of CMC; 2) preparing a biomimetic mineralized collagen scaffold: mixing the bionic mineralization solution and the acid-soluble type I collagen, putting the mixture into a dialysis bag, sealing the bag, putting the bag into a PBS (phosphate buffer solution), self-assembling and mineralizing the bag for 2 to 5 days, adding an alkaline CMC/ACP (ASP or ASC) solution into the dialysis bag, and replacing the PBS buffer solution; and dialyzing the dialysis bag in deionized water for 10-72 h after 1-3 days, replacing the deionized water for many times, centrifuging the solution in the bag to obtain collagen gel, and freeze-drying to obtain the biomimetic mineralized collagen scaffold. The invention adopts the synergy of collagen self-assembly and mineralization, realizes the mineralization in collagen fibers with higher efficiency, can integrate strontium element with osteogenesis promoting capability into a collagen scaffold, and has wide clinical application prospect. |
| priorityDate | 2017-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.