| abstract |
The invention belongs to field of pharmaceutical preparations, and in particular to a kind of thermo-sensitive gel drug delivery system in situ of chemotherapeutic immunity therapeutic alliance.The delivery system is made of pharmaceutical carrier peptide dendrimer (G4 arg), antitumor drug and thermo-sensitive gel host material PLGA PEG PLGA, antitumor drug is contained and carries medicine peptide dendrimer in formation in peptide dendrimer cavity, it is wrapped in by swelling process by medicine peptide dendrimer is carried in thermo-sensitive gel matrix, formation is injectable type colloidal sol at room temperature, is changed into the situ drug delivery system of gel under body temperature.The delivery system in situ of the present invention can form gel in tumor vicinity, slowly release and carry medicine peptides dendrimers molecular action in tumor tissues, the molecular action of peptides dendrimers generates NO in the macrophage in tumor tissues, with antitumor drug collective effect in tumour, chemotherapeutic immunity therapeutic alliance is formed, suppresses the development of tumour. |