http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107922460-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2896 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4703 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 |
| filingDate | 2015-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107922460-B |
| titleOfInvention | Novel TLR4 antagonists |
| abstract | The present invention relates to a peptide for inhibiting the TLR4 signaling pathway, a TLR4 antagonist comprising the peptide, and a composition for preventing or treating an autoimmune disease or an inflammatory disease. More particularly, it relates to a peptide which binds to the TLR4/MD2 complex to inhibit the secretion of interleukin-6 (IL-6), NO and ROS and the activation of nfkb and MAPKs, a TLR4 antagonist comprising the same, and a composition for preventing or treating autoimmune and inflammatory diseases. The peptide of the present invention has an excellent effect of inhibiting the secretion of interleukin-6 (IL-6), NO and ROS and the activation of nfkb and MAPKs by inhibiting the TLR4 signaling pathway induced by Lipopolysaccharide (LPS), and can be effectively used as a composition for preventing or treating autoimmune diseases and inflammatory diseases occurring via the TLR4 signaling pathway. |
| priorityDate | 2015-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 386.