| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3235
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3517
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3513
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3515
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3341
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-318
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-315
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-353
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-335
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-323 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
2014-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2020-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2020-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-107904239-B |
| titleOfInvention |
siRNA for inhibiting ADAMTS-5 gene and application thereof |
| abstract |
The invention discloses siRNA for inhibiting ADAMTS-5 genes and application thereof. The invention discloses a chemically modified double-stranded siRNA molecule, which is formed by complementing at least one strand of siRNA molecules shown in the following (1) to (13) through any chemical modification shown in the following (A). The siRNA disclosed by the invention can be used as a therapeutic drug for arthritis and related inflammation, and can realize the treatment of the arthritis by inhibiting the expression of inflammatory factors through local injection of the siRNA and a preparation thereof in a bone joint cavity. |
| priorityDate |
2014-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |