http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107903276-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-20 |
| filingDate | 2017-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107903276-B |
| titleOfInvention | A kind of method of asymmetric synthesis of cephalotaxine skeleton E ring |
| abstract | The present invention relates to a kind of catalysis method of asymmetric synthesis of cephalotaxine intermediate, with 10, 10a- dihydro -5H- [1, 3] dioxole simultaneously [4', 5':4, 5] benzo [1, 2-d] pyrrolo- [1, 2-a] azepine -8, 11- (6H, 9H)-diketone N is raw material, by the esterification of the enol oxygen atom of ketone, intramolecular asymmetry decarboxylation allylation, Wacker oxidation, Aldol condensation, selective catalytic hydrogenation and visible light and Ag/TiO2 and salung manganese (salen-Mn) are total to catalytic air oxidation and obtain crucial chiral intermediate (11bS, 12S, 14aS) -12- hydroxyl -13, 13- dimethoxy -5, 6, 11b, 12, 13, 14- hexahydro -1H- [ 1,3] simultaneously simultaneously [b] pyrrolo- [1,2-a] azepine -3 (2H) -one T, the ee value of product reach as high as 99% to [4', 5':4,5] benzo [1,2-d] pentamethylene to dioxole.Using chipal compounds as the asymmetric syntheses of starting material, cost is relatively low for the method, and catalytic efficiency is higher compared to diplomatic, and the total recovery that six steps synthesize E ring key intermediate T is 51.8%, has preferable industrial prospect. |
| priorityDate | 2017-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 166.