http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107903267-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-52 |
| filingDate | 2017-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107903267-B |
| titleOfInvention | Azo aromatic nitrogen mustard-chloroethyl nitrosourea coupled compound, preparation method and application |
| abstract | The present invention relates to compounds or pharmaceutically acceptable salts of the structure of formula (I): in the compound, the azo group is taken as a hypoxia activation pharmacophore, and the nitrogen-nitrogen double bond of the azo group is broken to release aromatic nitrogen mustard and O under the condition of tumor hypoxia 6 -BG analogues, which targetedly act as alkylating agents and AGT inhibitors in hypoxic regions, rendering tumor cells more sensitive to alkylating agents; furthermore, the CENUs pharmacophore in the compound can be decomposed to generate chloroethyl carbonium ions, so that the DNA interstrand cross-linking is caused, and the effect of inhibiting the growth of tumor cells is achieved. |
| priorityDate | 2017-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 115.