http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107899019-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G81-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G81-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-60 |
| filingDate | 2017-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107899019-B |
| titleOfInvention | Intelligent high-molecular bonding medicine for bonding cell penetrating peptide and preparation method thereof |
| abstract | The invention discloses an intelligent macromolecule bonding medicine of bonding cell penetrating peptide and a preparation method thereof, the macromolecule bonding medicine takes polylactide as a main chain, polyethylene glycol hydrophilic branched chain is introduced through carbon-nitrogen double bond with pH response, and simultaneously anti-tumor medicine and cell penetrating peptide are grafted, the preparation method is that oligomeric polyethylene glycol monomethyl ether with pH response, cell penetrating peptide C-TAT and anti-tumor medicine are bonded on degradable polymer through sulfydryl-alkene click reaction, thereby obtaining the macromolecule bonding medicine which can remove the protection of the oligomeric polyethylene glycol monomethyl ether in weak acid environment outside tumor cells, greatly increase the medicine reaching the inner part of the tumor by the cell penetrating peptide and improve the administration efficiency; the preparation method has mild conditions, simple operation, large drug-loading rate and controllability. |
| priorityDate | 2017-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.