| abstract |
Genetically modified non-human animals expressing human SIRPα and human IL-15 from the genome of the non-human animal are provided. Also provided are methods for making a non-human animal expressing human SIRPα and human IL-15 from the genome of the non-human animal, and methods of using the non-human animal expressing human SIRPα and human IL-15 from the genome of the non-human animal. These animals and methods have many uses in the art, including, for example, modeling human T cell and/or natural killer (NK) cell development and function, modeling human pathogen infection of human T cells and/or NK cells , and various in vivo screens. |