http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107880094-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J63-008 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J63-00 |
| filingDate | 2016-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107880094-B |
| titleOfInvention | Ursolic acid neutral cholesterol ester hydrolase inhibitor and application thereof |
| abstract | The invention provides an ursolic acid neutral cholesterol ester hydrolase inhibitor and application thereof, belonging to the technical field of biological medicines. The ursolic acid compound can strongly and selectively inhibit the activity of NCEH1, thereby improving the oral bioavailability of the carboxylic ester exogenous prodrug. The inhibitor can inhibit clopidogrel metabolism inactive products, and is used as a clopidogrel synergist. Such inhibitors may also be involved in fat metabolism by inhibiting ncih 1, alleviating the development of insulin resistance induced by ectopic deposition of lipids to impaired glucose tolerance. The IC of the compound (3-carboxypropionyl-ursolic acid) for inhibiting NCEH1 is found by in vitro activity measurement 50 Can reach 12 nanomole, and has no obvious inhibition on other human carboxylesterase (hCE2), and the selectivity is as high as 6919 times. In addition, the compound also has the advantages of good safety, simple preparation process, high synthesis yield and the like, and the compound is prompted to have good application prospect. |
| priorityDate | 2016-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1101.