| abstract |
The invention discloses a quinazoline derivative salt, its preparation method and application. The invention provides a quinazoline derivative (N-[4-(3-chloro-4-fluoroanilino)]-7-(3-morpholine propanol)-6-(2-fluoroacrylamide Base)-quinazoline, its structure is as shown in formula 1) salt, compared with known quinazoline derivatives, the salt of this quinazoline derivatives has one or more improved properties, at least has Better water solubility, among which monocitrate, monobenzenesulfonate and monoethylenedisulfonate also have the advantage of not being hygroscopic. |