| abstract |
In certain aspects, the present disclosure provides a soluble one-armed heteromeric polypeptide complex comprising an extracellular domain of a type I serine/threonine kinase receptor of the TGF-beta family or a type II serine of the TGF-beta family / extracellular domain of the threonine kinase receptor. In some embodiments, the present disclosure provides a soluble one-armed polypeptide complex comprising an extracellular domain of a type II receptor selected from ActRIIA, ActRIIB, TGFBRII, BMPRII, and MISRII. In some embodiments, the present disclosure provides a soluble one-armed polypeptide complex comprising an extracellular domain of a type I receptor selected from ALK1, ALK2, ALK3, ALK4, ALK5, ALK6, and ALK7. Optionally, the soluble complex is a heterodimer. In certain aspects, such soluble polypeptide complexes are useful in the treatment or prevention of various TGF-β-associated conditions, including without limitation those associated with, for example, cancer, muscle, bone, fat, red blood cell, metabolism, fibrosis, and TGF-β-affected conditions. Other tissue-related diseases and disorders affected by one or more ligands of the beta superfamily. |