| abstract |
The invention discloses a sericin hydrogel and a preparation method and application thereof, wherein the method comprises the step of simultaneously crosslinking a sericin aqueous solution obtained by extracting silkworm cocoons of specific silkworm fibroin deletion mutant varieties with two crosslinking agents to obtain the sericin hydrogel with new characteristics. The sericin hydrogel prepared by the method has new fluorescence characteristics, namely super-strong green and red fluorescence characteristics; the hydrogel has a microstructure different from that of the traditional hydrogel, and the hydrogel has a composite pore structure with two types of micropores; meanwhile, the rubber has the characteristics of deformation memory, injectability and in-situ gelling; the sericin hydrogel has good biocompatibility and cell adhesion, and has good controlled release effect on medicaments; the sericin hydrogel and the three-dimensional porous sericin biological scaffold obtained by freeze-drying the sericin hydrogel can be used as an extracellular matrix to support cell growth and promote nutrient exchange, and can be applied to repair of various tissue injuries and treatment of diseases. |