http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107828722-B
Outgoing Links
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classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70521 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0662 |
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filingDate | 2017-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2021-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2021-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-107828722-B |
titleOfInvention | Stem cell specifically expressing PD-1, and identification and separation method and application thereof |
abstract | The invention discloses stem cells specifically expressing programmed death receptor 1(PD-1), in particular stem cells derived from oral cavity, including but not limited to dental pulp stem cells, gingival stem cells (GMSCs), periodontal ligament stem cells (PDLSCs), dental papilla Stem Cells (SCAPs) and dental follicle Stem Cells (SCAPs)DFSCs) or any combination thereof, preferably comprising deciduous dental pulp mesenchymal stem cells (SHED) and/or permanent dental pulp mesenchymal stem cells (DPSC); other tissue-derived mesenchymal stem cells that do not initially express PD-1 but that express PD-1 after CRISPR modification are also included, e.g., CRISPR-modified PD-1 + Bone Marrow Mesenchymal Stem Cells (BMMSCs). The invention also discloses an identification and separation method of stem cells specifically expressing programmed death receptor 1(PD-1) and a method for preparing CRISPR modified PD-1 + Methods of mesenchymal stem cells and uses of the inventive mesenchymal stem cells expressing PD-1 in tissue regeneration, pain relief, chronic pain treatment and treatment of a range of diseases. |
priorityDate | 2016-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 238.