http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107827946-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d563a0ad5c915e9ad724a8da7655cb1f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-0011 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 |
| filingDate | 2017-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_063ce5f4181aadf3ba4f698f8da729b6 |
| publicationDate | 2018-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107827946-A |
| titleOfInvention | The preparation method of Exemestane |
| abstract | The preparation method of Exemestane of the present invention is related to cancer therapy drug field, and in particular to the preparation method of Exemestane, comprises the following steps：Paraformaldehyde, dimethylamine hydrochloride and isoamyl alcohol, under nitrogen protection, are added in four mouthfuls of reaction bulbs by the preparation of 6 methylene hero dienone ethylene ketals successively; it is heated to reflux band water 2h; then male dienone ethylene ketal is added, is reacted in 140 degree of insulated and stirreds, the reaction of high performance liquid chromatography tracing detection; 15h reactions terminate; room temperature is cooled to, distilled water washing is added, is dried after layering with anhydrous magnesium sulfate; solvent is recovered under reduced pressure, silica gel column chromatography obtains white solid；Second step, the preparation of Exemestane, under nitrogen protection, 6 methylene hero dienone ethylene ketals, p-methyl benzenesulfonic acid and tetrahydrofuran are added in four-hole bottle successively；Present invention process route is simple and direct, and raw material is easy to get, and cost is low, high income, and overcomes the defects of prior art is present, and is adapted to industrialized production. |
| priorityDate | 2017-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.