http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107827880-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4245 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 |
| filingDate | 2017-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107827880-B |
| titleOfInvention | Carbonitrile compound containing imidazole and 1,3, 4-oxadiazole structure and preparation method and application thereof |
| abstract | The invention discloses a carbonitrile compound containing imidazole and 1,3, 4-oxadiazole structures, and a preparation method and application thereof. The carbonitrile compound containing imidazole and 1,3, 4-oxadiazole structures consists of 4-chloro-2-cyano-5- (p-methylphenyl) -1 H The-imidazole-1-carbohydrazide and the substituted benzoic acid carry out cyclization reaction in phosphorus oxychloride under a reflux state, and after the reaction is finished, the reaction liquid is separated and purified to obtain the-imidazole-1-carbohydrazide-substituted benzoic acid. The preparation method is simple, the post-treatment is convenient, the obtained compounds show better anticancer activity, and the anticancer activity of the prepared compounds is determined by using a rapid tetrazole colorimetric method for human hepatoma cells, human lung cancer cells A549 and human colon cancer cells HCT 116. The bioassay result shows that the compound has certain inhibitory activity on all tested targets; the inhibition activity of most compounds on human colon cancer cell strain HCT116 and human liver cancer cell strain Huh7 is better than that of human lung cancer cell strain A549. |
| priorityDate | 2017-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.