http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107823177-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5036 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-003 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-08 |
| filingDate | 2017-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107823177-B |
| titleOfInvention | Preparation method of transfer 5-fluorouracil microspheres |
| abstract | The invention discloses a preparation method of transfer 5-fluorouracil microspheres, which comprises succinic anhydride modification, sodium alginate microsphere preparation, sodium alginate-chitosan microsphere preparation and sodium alginate-chitosan-carrageenan microsphere preparation, and has the advantages that the surface of the sodium alginate microsphere is wrapped with two polysaccharide layers to form an LBL structure, the surface gap of the prepared core-shell type multilayer microsphere is reduced, the transferred active ingredients can reach the colon through acid gastric juice to achieve definite targeted therapeutic effect, the sodium alginate-chitosan-carrageenan microsphere system shows extremely high sensitivity in a colon weak alkaline environment with the pH of about 7.4, the swelling ratio of the sodium alginate-chitosan-carrageenan microsphere system in 30 minutes can reach more than 20, and the sodium alginate-chitosan-carrageenan microsphere is expected to be used as a carrier of colon targeted drug delivery of a special preparation, and has a relatively high market prospect. |
| priorityDate | 2017-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 80.