http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107817307-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-02 |
| filingDate | 2017-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107817307-B |
| titleOfInvention | Method for separating and determining paszidine and related impurities thereof by HPLC method |
| abstract | The invention belongs to the field of analytical chemistry, and particularly relates to a method for separating and determining paszidine and related impurities thereof by an HPLC method. The chromatographic column adopted in the method is characterized in that octadecylsilane chemically bonded silica is used as a filler, mobile phase A and mobile phase B are adopted for gradient elution, and the gradient elution enters a detector for detection; the related substances comprise isoniazid, para-aminosalicylic acid and related impurities; the related impurities are one or more of A-E; the mobile phase A is phosphate buffer solution, and the mobile phase B is methanol. The method can simultaneously separate and measure isoniazid, para-aminosalicylic acid and related impurities A-E in the paszid, and improves the separation and detection efficiency compared with the prior art; can more accurately ensure the quality controllability of the raw material drug of the paszidine and the preparation thereof, and finally determine the safety and effectiveness of the product. |
| priorityDate | 2017-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.