http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107815470-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-88 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-88 |
| filingDate | 2017-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107815470-B |
| titleOfInvention | Preparation method of liposome/gel composite gene activation scaffold |
| abstract | The invention relates to a preparation method of a liposome/gel composite gene activation scaffold, belonging to the technical field of biomedicine; the invention uses TAT modified liposome as an efficient gene transfection vector, and the TAT modified liposome is encapsulated in hyaluronic acid gel cross-linked with MMPs sensitive peptide, thereby constructing an MMPs sensitive gene activation scaffold internally encapsulating the liposome; the cells secrete MMPs in the migration and proliferation processes, so that the gel is degraded, on one hand, a space is created for the migration and proliferation of the cells, the network structure of the gel is prevented from becoming a physical barrier for the migration and proliferation of the cells, on the other hand, TAT-liposome is released, and high-efficiency in-situ transfection is carried out on the surrounding cells, so that growth factors are expressed and secreted, and tissue repair and regeneration are promoted. |
| priorityDate | 2017-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.