http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107814745-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_53aa7f636acc025f5f453aaaedf35467 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C241-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C245-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C243-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C241-02 |
| filingDate | 2016-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24a0bcc98976cbb31bf8e413bbcdcfe0 |
| publicationDate | 2018-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107814745-A |
| titleOfInvention | A kind of preparation method of 3 procarbazine sulfate |
| abstract | The present invention relates to a kind of preparation method of 3 procarbazine sulfate, including diazotising, reduction, purifying, into salt the step of.In the step of diazotising and reduction, it is in highly acid to keep reaction solution using concentrated hydrochloric acid, ensures that the smooth of reaction is carried out completely.In reduction step, using zinc powder concentrated hydrochloric acid as reducing agent, instead of sodium thiosulfate, sodium hydrogensulfite, stannous chloride hydrochloric acid etc., not only reducing property is good, high income, shortens the reaction time, the impurity such as the zinc hydroxide generated after reaction are easy to remove, and make product impurity few, and purity is high.Eluted in salt-forming steps with acetone, both improved the purity of product, in turn ensure that the outward appearance of product.This preparation method process stabilizing is reliable, easily operated, product purity height (high performance liquid chromatography surveys its content >=99.1%), yield >=42%, fully meets needs of the market to 3 procarbazine sulfate. |
| priorityDate | 2016-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.