| abstract |
The present invention relates to a prime-boost regimen involving administration of at least one mRNA construct, such as using said construct in a "boost" administration following a "prime" administration of some other antigenic composition. Said inventive protocol can be used in particular for the induction of an immune response in a subject, and/or for the vaccination of said subject from infection with one or more pathogens, and/or for the treatment or prophylaxis of one or more Various diseases or conditions, including tumors or cancers, allergies or autoimmune diseases and/or diseases or conditions associated with infection from pathogens. The invention further describes methods, uses, vaccination compositions, kits and packaged vaccine components in connection with or for use in one or more of the described regimens. |