http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107802610-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2866 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2013 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-38 |
| filingDate | 2017-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107802610-B |
| titleOfInvention | Isosorbide mononitrate sustained-release tablet and preparation method thereof |
| abstract | A isosorbide mononitrate sustained release tablet and a preparation method thereof belong to the technical field of pharmaceutical preparations and comprise a sustained release tablet core and a coating layer, wherein the sustained release tablet core is prepared from the following raw materials in percentage by mass: 5-15% of isosorbide mononitrate, 2-8% of adhesive, 10-30% of slow-release framework material, 50-80% of filler and 0.5-5% of lubricant; the coating layer is composed of the following raw materials by mass percent: 60-75% of ethyl cellulose, 10-15% of titanium dioxide and 10-15% of talcum powder, and the weight of the tablet after coating is increased by 1-1.5%. According to the tablet, the montan wax is used as a slow release framework in the tablet core, and the ethyl cellulose is used as a slow release coating, so that the slow release effect of the tablet is realized through double slow release effects. The dosage of the montan wax in the tablet core is controlled to be 2 times of that of the main drug, in addition, the over-thin ethyl cellulose slow-release coating layer can cause the main drug to be suddenly released in a large quantity, and the over-thick ethyl cellulose slow-release coating layer can cause the main drug to be dissolved too slowly or not to be dissolved. |
| priorityDate | 2017-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.