| abstract |
The invention belongs to the field of medicinal chemistry antiviral, and relates to an isoquinolinone compound represented by formula (I) or its stereoisomer, pharmaceutically acceptable salt, solvate or crystal and its preparation and its use as a therapeutic or The use of medicines for preventing viral infectious diseases such as hepatitis B virus (HBV), especially the application as medicines for hepatitis B surface antigen inhibitors (HBV Surface antigen inhibitors) and hepatitis B DNA inhibitors (HBV DNA production inhibitors). The compound of the present invention has significant activity of inhibiting hepatitis B surface antigen and hepatitis B DNA, and in the future, combined with nucleoside drugs or other drugs, it may significantly improve the probability of curing hepatitis B, and has excellent clinical application prospects. |