| abstract |
The invention discloses a preparation method of 3-fluorooxetane-3-methanol and its intermediate, comprising the following steps: in an organic solvent, performing a ring-closing reaction with a compound shown in formula 5 and a strong base , to obtain the compound shown in formula 6; R 1 is methylsulfonyl, p-toluenesulfonyl, p-trifluoromethylbenzenesulfonyl or trifluoromethylsulfonyl; in an organic solvent, magnesium and formula 6 Compound 7 was reacted to generate compound 7. This method has the characteristics of high yield, simple operation, simple post-treatment, etc., and is suitable for large-scale production. |