http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107778279-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D319-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D319-06 |
| filingDate | 2017-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107778279-B |
| titleOfInvention | Preparation method of atorvastatin calcium intermediate |
| abstract | The invention belongs to the technical field of pharmaceutical chemistry, and particularly relates to a preparation method of an atorvastatin calcium intermediate. In the invention, an intermediate compound II is taken as a starting material and is gradually converted into a lithium reagent compound III and an aldehyde compound IV, then the intermediate compound III and the aldehyde compound IV react with hydroxylamine to generate an oxime compound V, an oxime group is dehydrated to obtain a cyano group I-A, and then the target compound I is obtained through upper protection. Compared with the prior report, the route effectively avoids the use of highly toxic substances of sodium cyanide and hydrocyanic acid, and the reaction in the whole route is common, the condition is mild, and the yield is better. Is more beneficial to the large-scale industrial production of the intermediate I. |
| priorityDate | 2017-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 266.